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The committed step of fatty acid synthesis is the formation of ________________.

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Choose the correct answer from the list below. Not all of the answers will be used. -Fatty acid synthesis primarily takes place in the cellular location ________________.


A) malonyl CoA
B) three
C) four
D) C16-acyl ACP
E) cytosol
F) glycolysis
G) acetyl CoA
H) β-hydroxybutyrate
I) acetyl CoA carboylase
J) AMP-dependent protein kinase
K) oxaloacetate
L) malic enzyme
M) citrate

N) A) and B)
O) B) and E)

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The coenzyme required for fatty acid synthesis is ________________.

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Where are the enzymes for fatty acid elongation and desaturation in eukaryotes?

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In eukaryotes, the enzymes tha...

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Acetyl carboxylaseis globally regulated by:


A) allosteric inhibitors and activators
B) phosphorylation and dephosphorylation.
C) zymogen activation
D) h the binding of cAMP.
E) None of the above.

F) A) and B)
G) A) and C)

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Prostaglandins and thromboxanes are synthesized from ________________, a 20-carbon fatty acid.

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Choose the correct answer from the list below. Not all of the answers will be used. -The committed step in fatty acid synthesis is inactivated by the regulatory enzyme ________________.


A) malonyl CoA
B) three
C) four
D) C16-acyl ACP
E) cytosol
F) glycolysis
G) acetyl CoA
H) β-hydroxybutyrate
I) acetyl CoA carboylase
J) AMP-dependent protein kinase
K) oxaloacetate
L) malic enzyme
M) citrate

N) B) and C)
O) B) and K)

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Describe the allosteric stimulatory effect of citrate on acetyl CoA carboxylase.

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The inactive form of acetyl Co...

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The carrier of an acyl chain through the synthetic protein complex is:


A) ACP.
B) a serum albumin.
C) acetyl coenzyme A.
D) a biotin-activated complex.
E) None of the above.

F) D) and E)
G) C) and E)

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Describe the regulation of fatty acid synthesis by AMP and citrate.

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AMP is a low-energy molecule that is pro...

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Double bonds are introduced into fatty acids in the ________________ compartment of the cell.

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endoplasmi...

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Activation of acetyl CoA results in the production of ________________.

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How are fatty acids larger than the 16 carbons formed?


A) by elongation reactions catalyzed by enzymes on the endoplasmic reticulum
B) by 1-carbon additions at the mitochondrial membrane
C) by elongation reactions catalyzed by enzymes in the peroxisomes
D) All of the above.
E) None of the above.

F) B) and D)
G) A) and E)

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The major product of mammalian fatty acid synthesis is ________________.

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a C16 fatt...

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Citrate serves as a signal for a high-energy state as it stimulates ________________.

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acetyl CoA...

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The function of the enzyme acyl CoA synthetase is:


A) lipolysis to release free glyceraldehyde.
B) ATP-dependent reduction of acetyl-CoA prior to activation.
C) ATP-dependent activation of fatty acids using CoA.
D) All of the above.
E) None of the above.

F) B) and C)
G) B) and E)

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Insulin leads to:


A) an activation of fatty acid synthesis.
B) an inhibition of fatty acid synthesis.
C) a phosphorylation of proteins
D) a decrease of protein phosphatase hydrolysis of fatty acid synthesis enzymes
E) A decrease in pyruvate transport into mitochondria

F) A) and E)
G) C) and E)

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Describe the chemistry for fatty acid synthesis at the stage when a 2-carbon molecule reacts with a 3-carbon molecule to give a 4-carbon molecule and a 1-carbon molecule..

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This is the activation and con...

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What enzyme catalyzes the committed step in fatty acid synthesis?


A) Enoyl reductase
B) Acetyl CoA carboxylase
C) Transacylase reductase
D) 3-Hydroxyacyl dehydratase
E) None of the above.

F) C) and D)
G) A) and B)

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Which compound inhibits the entry of fatty acyl CoA into the mitochondria as a function of the cell being in the high-energy state?


A) malonyl CoA
B) carnitine acyltransferase
C) inhibition of acetyl CoA carboxylase
D) All of the above.
E) None of the above.

F) A) and D)
G) A) and E)

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