Question 1

The M and N antigens are found in which glycoprotein?

Accepted Answer

A)   Glycophorin A
B)   Glycophorin B
C)   Glycophorin C
D)   Band 3E) B) and C)
F) A) and B)

Question 2

What will happen to I antigen expression when ABH sugars are removed from red blood cells?

Accepted Answer

A)   Increased expression
B)   Decreased expression
C)   No effect
D)   None of the aboveE) None of the above
F) B) and D)

Question 3

What name is attached to the Ena antigen?

Accepted Answer

A)   Envelope
B)   Enterprise
C)   Envision
D)   EpitopeE) C) and D)
F) B) and D)

Question 4

Persons who phenotype negative for U antigen lack Ss-SGP because of a partial or complete deletion of .

Accepted Answer

A)   GPA
B)   GPB
C)   N-acetylneuraminic acid
D)   N-acetylgalactosamineE) A) and B)
F) A) and C)

Question 5

Why are Lewis antibodies not generally implicated in hemolytic disease of the newborn?

Accepted Answer

A)   Lewis antigens are well developed at birth.
B)   Lewis antibodies are IgM and cannot cross the placenta.
C)   Lewis antigens can readily dissociate from the red blood cell upon transfusion of Lewis-positive cells.
D)   Lewis antibodies do not bind complement.E) A) and C)
F) A) and D)

Question 6

The Ii antigens are found on the membranes of which structures?

Accepted Answer

A)   Platelets
B)   Leukocytes
C)   Red blood cells
D)   All of the aboveE) A) and D)
F) A) and C)

Question 7

I and i antigens are found in plasma, serum, and what other possible source?

Accepted Answer

A)   Breast milk
B)   Urine
C)   Saliva
D)   All of the aboveE) A) and B)
F) A) and C)

Question 8

Which of the following are written in the order of allele, antigen, and phenotype?

Accepted Answer

A)   A1, A1, A1
B)   A1, A1, A1
C)   A1, A1, A1
D)   A1, A1, A1E) A) and D)
F) B) and D)

Question 9

Which of the following is not involved in the Kell blood group system?

Accepted Answer

A)   Jsa
B)   K
C)   Kpb
D)   JkaE) A) and B)
F) All of the above

Question 10

A patient presented in the emergency room needing to be transfused ASAP. According to the computer, the patient had a Kell antibody 5 years ago. The antibody screen is negative now. Of the following, the best procedure to obtain suitable blood for transfusion is:

Accepted Answer

A)   to use immediate spin crossmatch compatible blood.
B)  to take the time to crossmatch the units of blood through the AHG phase.
C)  To antigen type the units for Kell and completely crossmatch the negative ones.
D)  To assume the electronic crossmatch is acceptable.E) All of the above
F) B) and C)

Question 11

The genes that code for GPA and GPB are closely linked on the long arm of which chromosome?

Accepted Answer

A)   9
B)   11
C)   4
D)   15E) A) and D)
F) All of the above

Question 12

Which of the following is known to enhance K antigen expression in the antihuman globulin test?

Accepted Answer

A)   LISS
B)   DTT
C)   Albumin
D)   Polyethylene glycolE) All of the above
F) None of the above

Question 13

Which blood group system is not based on carbohydrates?

Accepted Answer

A)   Lewis
B)   Rh
C)   P
D)   ABOE) A) and D)
F) A) and C)

Question 14

Serologic tests determine a person's:

Accepted Answer

A)   genotype.
B)   haplotype.
C)   phenotype.
D)   all of the above.E) B) and C)
F) A) and D)

Question 15

Which of the following may be a possible cause for the lack of expression of Lewis antigens during pregnancy?

Accepted Answer

A)   Increased ratio of plasma lipoproteins to RBC mass
B)   Decreased ratio of plasma lipoproteins to RBC mass
C)   Antigenic sites blocked by IgG antibody
D)   Antigenic sites blocked by IgM antibodyE) B) and D)
F) None of the above

Question 16

How is Leb substance formed?

Accepted Answer

A)   L-fucose is added to subterminal N-acetylglucosamine of type 1 H substance.
B)   L-fucose is added to subterminal N-acetylglucosamine of type 2 H substance.
C)   Lea and Leb are codominant alleles located on chromosome 19.
D)   Leb is secreted into plasma in the absence of fucosyltransferase.E) B) and C)
F) None of the above

Question 17

Hemolysis associated with ficin-treated cells is more common with which red blood cells?

Accepted Answer

A)   Jk(a+b+) 
B)   Jk(a-b+) 
C)   Jk(a+b-) 
D)   All of the aboveE) All of the above
F) A) and B)

Question 18

Why is it strongly recommended that only homozygous cells be used when ruling out Kidd antibodies?

Accepted Answer

A)   Anti-Jka may appear compatible with homozygous cells [Jk(a+b-) ].
B)   Anti-Jka may appear compatible with heterozygous cells [Jk(a+b+) ].
C)   It will reduce the number of false-positive results.
D)   Options A and CE) None of the above
F) C) and D)

Question 19

Where are the Duffy antigens found?

Accepted Answer

A)   Red blood cells
B)   Platelets
C)   Lymphocytes
D)   All of the aboveE) A) and D)
F) C) and D)

Question 20

Dithiothreitol (DTT) , when used alone, can destroy antigens in which blood group system?

Accepted Answer

A)   Duffy
B)   Kell
C)   Kidd
D)   LewisE) B) and C)
F) A) and B)

Exam 8: Blood Group Terminology and Common Blood Groups

Which blood group system is not based on carbohydrates?

Correct AnswerverifiedShow Answer

Which of the following are written in the order of allele, antigen, and phenotype?

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I and i antigens are found in plasma, serum, and what other possible source?

Correct AnswerverifiedShow Answer

Persons who phenotype negative for U antigen lack Ss-SGP because of a partial or complete deletion of .

Correct AnswerverifiedShow Answer

A patient presented in the emergency room needing to be transfused ASAP. According to the computer, the patient had a Kell antibody 5 years ago. The antibody screen is negative now. Of the following, the best procedure to obtain suitable blood for transfusion is:

Correct AnswerverifiedShow Answer

The genes that code for GPA and GPB are closely linked on the long arm of which chromosome?

Correct AnswerverifiedShow Answer

The M and N antigens are found in which glycoprotein?

Correct AnswerverifiedShow Answer

Why is it strongly recommended that only homozygous cells be used when ruling out Kidd antibodies?

Correct AnswerverifiedShow Answer

Serologic tests determine a person's:

Correct AnswerverifiedShow Answer

What name is attached to the Ena antigen?

Correct AnswerverifiedShow Answer

What will happen to I antigen expression when ABH sugars are removed from red blood cells?

Correct AnswerverifiedShow Answer

Which of the following is not involved in the Kell blood group system?

Correct AnswerverifiedShow Answer

Which of the following may be a possible cause for the lack of expression of Lewis antigens during pregnancy?

Correct AnswerverifiedShow Answer

Which of the following is known to enhance K antigen expression in the antihuman globulin test?

Correct AnswerverifiedShow Answer

Why are Lewis antibodies not generally implicated in hemolytic disease of the newborn?

Correct AnswerverifiedShow Answer

Dithiothreitol (DTT) , when used alone, can destroy antigens in which blood group system?

Correct AnswerverifiedShow Answer

The Ii antigens are found on the membranes of which structures?

Correct AnswerverifiedShow Answer

How is Leb substance formed?

Correct AnswerverifiedShow Answer

Hemolysis associated with ficin-treated cells is more common with which red blood cells?

Correct AnswerverifiedShow Answer

Where are the Duffy antigens found?

Correct AnswerverifiedShow Answer

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What name is attached to the En^a antigen?

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How is Le^b substance formed?

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