Question 1

In prokaryotes the first amino acid incorporated into a polypeptide is a __________.

Accepted Answer

N-formyl-m...

Question 2

Which of the following is the best definition of translation?

Accepted Answer

A)  a process by which pre-mRNA is transformed into mature mRNA
B)  the process by which pre-mRNA is translated by ribozymes to produce proteins
C)  a process by which a gene is converted into mRNA
D)  the process by which ribosomes read the genetic message to produce a protein
E)  a process by which a gene is converted into a proteinF) All of the above
G) A) and D)

Question 3

Translation initiation in eukaryotes involves scanning of the mRNA to locate a favorable AUG.

Accepted Answer

A) True 
 B)False

Question 4

eIF4A is a member of the DEAD protein family that has RNA helicase activity.

Accepted Answer

A) True 
 B)False

Question 5

Similar to prokaryotes,eukaryotic translation incorporates an N-formyl-methionine as the first amino acid.

Accepted Answer

A) True 
 B)False

Question 6

Most eukaryotic mRNAs have 5' caps that function in translation initiation instead of Shine -Dalgarno sequences found in prokaryotes.

Accepted Answer

A) True 
 B)False

Question 7

There are _________ aminoacyl-tRNA synthetases,one for each amino acid.

Accepted Answer

The answer of There are _________ aminoacyl-tRNA synthetases,one for each...

Question 8

Which of the following is not part of the 30S initiation complex?

Accepted Answer

A)  IF1,IF2,and IF3
B)  5S rRNA
C)  16S rRNA
D)  amino-acyl tRNA
E)  mRNAF) D) and E)
G) A) and D) B

Question 9

eIF1 and eIF1A appear to encourage formation of a stable 48S complex by dissociating improper 40S and mRNA complexes.

Accepted Answer

A) True 
 B)False

Question 10

Picornavirus mRNAs are not capped,yet they can still out compete host mRNAs for binding to the ribosome by

Accepted Answer

A)  inactivating host Cap binding protein,eIF4F.
B)  degrading host mRNA.
C)  having a stronger affinity for the ribosome.
D)  inactivation of host RNases.
E)  inactivation of host Cap binding protein,eIF2B.F) A) and C)
G) C) and E) A

Question 11

The _______ subunit of the E.coli ribosome binds the mRNA and tRNA while the _________ subunit has the peptidyl transferase activity.

Accepted Answer

The answer of The _______ subunit of the E.coli ribosome...

Question 12

Which of the following eukaryotic transcription factors is homologous to the prokaryotic transcription factor IF2?

Accepted Answer

A)  eIF1A
B)  eIF2B
C)  eIF3
D)  eIF4G
E)  eIF5BF) A) and D)
G) A) and E)

Question 13

Match the following eukaryotic translation initiation factors with their correct function.
-This initiation factor aids in ribosome scanning to locate the initiation codon.B

Accepted Answer

A)  eIF2
B)  eIF1
C)  eIF3
D)  eIF4F
E)  eIF6Bloom's Level: 1.RememberSection: 17.02F) B) and E)
G) A) and E)

Question 14

The let-7 miRNA blocks _________________ initiation in human cells.

Accepted Answer

The answer of The let-7 miRNA blocks _________________ initiation in...

Question 15

Match the following eukaryotic translation initiation factors with their correct function.
-This initiation factor binds to the 40S subunit and inhibits reassociation of the 40S and 60S subunits.C

Accepted Answer

A)  eIF2
B)  eIF1
C)  eIF3
D)  eIF4F
E)  eIF6Bloom's Level: 1.RememberSection: 17.02F) A) and D)
G) None of the above C

Question 16

Match the following eukaryotic translation initiation factors with their correct function.
-This initiation factor binds to the 60S subunit and inhibits reassociation of the 40S and 60S subunits.E

Accepted Answer

A)  eIF2
B)  eIF1
C)  eIF3
D)  eIF4F
E)  eIF6Bloom's Level: 1.RememberSection: 17.02F) All of the above
G) A) and B)

Question 17

A(n)_______________ is defined as the area between an initiation codon and a downstream termination codon located in the same reading frame.

Accepted Answer

The answer of A(n)_______________ is defined as the area between...

Question 18

Which of the following molecules does not interact with eIF4G?

Accepted Answer

A)  Cap
B)  alternative protein(x) 
C)  Pab1p
D)  eIF3
E)  eIF2F) A) and C)
G) A) and B)

Question 19

E.coli $\sigma$32 temperature sensitive expression is an example of transcriptional control.

Accepted Answer

A) True 
 B)False

Question 20

Match the following eukaryotic translation initiation factors with their correct function.
-This initiation factor is a Cap binding protein.D

Accepted Answer

A)  eIF2
B)  eIF1
C)  eIF3
D)  eIF4F
E)  eIF6Bloom's Level: 1.RememberSection: 17.02F) C) and D)
G) B) and E)

Exam 17: The Mechanism of Translation I: Initiation

In prokaryotes the first amino acid incorporated into a polypeptide is a __________.

Correct AnswerverifiedN-formyl-m...View AnswerShow Answer

Which of the following is the best definition of translation?

Correct AnswerverifiedShow Answer

Translation initiation in eukaryotes involves scanning of the mRNA to locate a favorable AUG.

Correct AnswerverifiedShow Answer

eIF4A is a member of the DEAD protein family that has RNA helicase activity.

Correct AnswerverifiedShow Answer

Similar to prokaryotes,eukaryotic translation incorporates an N-formyl-methionine as the first amino acid.

Correct AnswerverifiedShow Answer

Most eukaryotic mRNAs have 5' caps that function in translation initiation instead of Shine -Dalgarno sequences found in prokaryotes.

Correct AnswerverifiedShow Answer

There are _________ aminoacyl-tRNA synthetases,one for each amino acid.

Correct AnswerverifiedShow Answer

Which of the following is not part of the 30S initiation complex?

Correct AnswerverifiedB

eIF1 and eIF1A appear to encourage formation of a stable 48S complex by dissociating improper 40S and mRNA complexes.

Correct AnswerverifiedShow Answer

Picornavirus mRNAs are not capped,yet they can still out compete host mRNAs for binding to the ribosome by

Correct AnswerverifiedA

The _______ subunit of the E.coli ribosome binds the mRNA and tRNA while the _________ subunit has the peptidyl transferase activity.

Correct AnswerverifiedShow Answer

Which of the following eukaryotic transcription factors is homologous to the prokaryotic transcription factor IF2?

Correct AnswerverifiedShow Answer

Match the following eukaryotic translation initiation factors with their correct function. -This initiation factor aids in ribosome scanning to locate the initiation codon.B

Correct AnswerverifiedShow Answer

The let-7 miRNA blocks _________________ initiation in human cells.

Correct AnswerverifiedShow Answer

Match the following eukaryotic translation initiation factors with their correct function. -This initiation factor binds to the 40S subunit and inhibits reassociation of the 40S and 60S subunits.C

Correct AnswerverifiedC

Match the following eukaryotic translation initiation factors with their correct function. -This initiation factor binds to the 60S subunit and inhibits reassociation of the 40S and 60S subunits.E

Correct AnswerverifiedShow Answer

A(n)_______________ is defined as the area between an initiation codon and a downstream termination codon located in the same reading frame.

Correct AnswerverifiedShow Answer

Which of the following molecules does not interact with eIF4G?

Correct AnswerverifiedShow Answer

E.coli σ\sigmaσ 32 temperature sensitive expression is an example of transcriptional control.

Correct AnswerverifiedShow Answer

Match the following eukaryotic translation initiation factors with their correct function. -This initiation factor is a Cap binding protein.D

Correct AnswerverifiedShow Answer

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N-formyl-m...
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B

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A

The _ subunit of the E.coli ribosome binds the mRNA and tRNA while the ___ subunit has the peptidyl transferase activity.

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C

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E.coli $\sigma$ ³² temperature sensitive expression is an example of transcriptional control.

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